The artist has donated the complete sum of his £25,000 award winnings to the trust for venues, which functions to protect the Britain's independent music venues.
He was given the award on October 16 as his latest record his work was named the outstanding release of the previous year.
He has decided to hand the money over to the Music Venues Trust, in acknowledgment of the vital role grassroots venues had in his early career.
"I personally would not have achieved my current career if it hadn't been for all the gigs I did around the region, and further afield, when I was beginning," remarked Fender. "These locations are renowned, but they are facing challenges."
From early 2023 onward, more than 150 of these spaces have shut down – about one-sixth of the whole industry in the UK.
Recently, well-known musicians such as the band Pulp, Coldplay, the singer Katy Perry and Ed Sheeran have all supported the MVT in its attempts to help venues survive, by including a minor surcharge to their ticket costs, which supports local stages.
Sam Fender also joined in, raising in excess of £100,000 on his 2024 arena tour to help 38 grassroots venues across the UK.
These funds assisted locations that were facing potential shutdown due to difficulties stemming from floods, fire incidents and bereavements, as well as regulatory hurdles, legal disputes and neighbor objections.
Other venues were granted monetary aid in improving facilities and sound and lighting systems that directly benefitted performers and concertgoers.
"The concept that revenue from concerts in big venues helps the independent spots, where it all starts for musicians like me, is just logical," Sam Fender has commented.
Fender is among several artists to contribute his Mercury Prize winnings to worthy causes.
When they earned the award in the mid-90s for their release the album, vocalist Jarvis Cocker announced that the band would donate their cash to the charity War Child.
During 2002, musician she split her prize among a few charities, including the children's charity and a Sickle Cell organization.
"I also gave a grand to my local community centre, to their classes, because I did gymnastics when I was a child and they required new equipment," she shared with the media.
In recent years, they gave their winnings to the community center that developed their band, as well as other independent music bodies.
And winners that year the group gave their winnings to a multiple sclerosis charity after a close contact was found to have the illness.
"Receiving the award was sufficient," remarked singer Heather Small. "The prize was the bonus but we didn't require the bonus, because we had the cake. So our winning affected another person's life."
Recently, the trust announced it had protected two local spots in the South East, by placing them under local control.
The first in that area and The Croft in the city were acquired under the Own Our Venues scheme, which is backed by Arts Council England and enthusiasts who acquire "ownership units" in the venues.